A review. Wet-chem. approaches to multi-component hybrid nanocrystals (HNCs), that incorporate nanoscale domains of different semiconductor, metallic and/or oxide materials interconnected through inorg. junctions, are illustrated and discussed. Control of interfacial lattice strain and surface energy in liq. media can be achieved within the frame of seeded-growth synthesis techniques, leading to structurally complex HNCs with purposely engineered compositional and geometric parameters. Various topol. configurations are analyzed, including concentric core/shell architectures and hetero-oligomers grouping spherical and anisotropically shaped material sections. The most significant chem.-phys. properties and technol. advantages offered by such multifunctional HNCs are also briefly highlighted.