Systems and methods are described for transmitting data over physical channels to provide a high speed, low latency interface such as between a memory controller and memory devices. Controller-side and memory-side embodiments of such channel interfaces are disclosed which require a low pin count and have low power utilization. In some embodiments of the invention, different voltage, current, etc. levels are used for signaling and more than two levels may be used, such as a vector signaling code wherein each wire signal may take on one of four signal values.