000222947 001__ 222947
000222947 005__ 20190317000555.0
000222947 0247_ $$2doi$$a10.1126/science.aah3783
000222947 022__ $$a1095-9203
000222947 02470 $$2ISI$$a000387326300036
000222947 037__ $$aARTICLE
000222947 245__ $$aRed squirrels in the British Isles are infected with leprosy bacilli
000222947 269__ $$a2016
000222947 260__ $$aWashington$$bAmerican Association for the Advancement of Science$$c2016
000222947 300__ $$a4
000222947 336__ $$aJournal Articles
000222947 520__ $$aLeprosy, caused by infection with Mycobacterium leprae or the recently discovered Mycobacterium lepromatosis, was once endemic in humans in the British Isles. Red squirrels in Great Britain (Sciurus vulgaris) have increasingly been observed with leprosy-like lesions on the head and limbs. Using genomics, histopathology, and serology, we found M. lepromatosis in squirrels from England, Ireland, and Scotland, and M. leprae in squirrels from Brownsea Island, England. Infection was detected in overtly diseased and seemingly healthy animals. Phylogenetic comparisons of British and Irish M. lepromatosis with two Mexican strains from humans show that they diverged from a common ancestor around 27,000 years ago, whereas the M. leprae strain is closest to one that circulated in Medieval England. Red squirrels are thus a reservoir for leprosy in the British Isles.
000222947 700__ $$aAvanzi, C.
000222947 700__ $$aDel-Pozo, J.
000222947 700__ $$aBenjak, A.
000222947 700__ $$aStevenson, K.
000222947 700__ $$aSimpson, V. R.
000222947 700__ $$aBusso, P.
000222947 700__ $$aMcluckie, J.
000222947 700__ $$aLoiseau, C.
000222947 700__ $$aLawton, C.
000222947 700__ $$aSchoening, J.
000222947 700__ $$aShaw, D. J.
000222947 700__ $$aPiton, J.
000222947 700__ $$aVera-Cabrera, L.
000222947 700__ $$aVelarde-Felix, J. S.
000222947 700__ $$aMcdermott, F.
000222947 700__ $$aGordon, S. V.
000222947 700__ $$0243892$$aCole, S. T.$$g177247
000222947 700__ $$aMeredith, A. L.
000222947 773__ $$j354$$k6313$$q744-747$$tScience
000222947 8564_ $$s642335$$uhttps://infoscience.epfl.ch/record/222947/files/Avanzi.SM.pdf$$zn/a
000222947 8564_ $$s1329996$$uhttps://infoscience.epfl.ch/record/222947/files/Avanzi_et_al_Science.pdf$$yn/a$$zn/a
000222947 909C0 $$0252302$$pUPCOL$$xU11742
000222947 909CO $$ooai:infoscience.tind.io:222947$$pSV$$particle$$qGLOBAL_SET
000222947 917Z8 $$x241454
000222947 937__ $$aEPFL-ARTICLE-222947
000222947 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000222947 980__ $$aARTICLE