Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases

Quantitative phase microscopy (QPM) has recently emerged as a powerful label-free technique in the field of living cell imaging allowing to non-invasively measure with a nanometric axial sensitivity cell structure and dynamics. Since the phase retardation of a light wave when transmitted through the observed cells, namely the quantitative phase signal (QPS), is sensitive to both cellular thickness and intracellular refractive index related to the cellular content, its accurate analysis allows to derive various cell parameters and monitor specific cell processes, which are very likely to identify new cell biomarkers. Specifically, quantitative phase-digital holographic microscopy (QP-DHM), thanks to its numerical flexibility facilitating parallelization and automation processes, represents an appealing imaging modality to both identify original cellular biomarkers of diseases as well to explore the underlying pathophysiological processes.


Editor(s):
Popescu, G
Park, Y
Published in:
Quantitative Phase Imaging Ii, 9718, UNSP 97180K
Presented at:
2nd Confernce on Quantitative Phase Imaging ((QPI II), San Francisco, CA, FEB 14-17, 2016
Year:
2016
Publisher:
Bellingham, Spie-Int Soc Optical Engineering
ISSN:
0277-786X
ISBN:
978-1-62841-952-8
Keywords:
Laboratories:




 Record created 2016-10-18, last modified 2018-09-13


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)