000221807 001__ 221807
000221807 005__ 20190317000540.0
000221807 0247_ $$2doi$$a10.7554/eLife.15798
000221807 022__ $$a2050-084X
000221807 02470 $$2ISI$$a000379408800001
000221807 037__ $$aARTICLE
000221807 245__ $$aTarget-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior
000221807 269__ $$a2016
000221807 260__ $$aCambridge$$bElife Sciences Publications Ltd$$c2016
000221807 300__ $$a11
000221807 336__ $$aJournal Articles
000221807 520__ $$aGoal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal neurons in primary somatosensory barrel cortex (S1) projecting to either primary motor cortex (M1) or secondary somatosensory cortex (S2) during a whisker detection task, in which thirsty mice learn to lick for water reward in response to a whisker deflection. Whisker stimulation in 'Good performer' mice, but not 'Naive' mice, evoked long-lasting biphasic depolarization correlated with task performance in S2-projecting (S2-p) neurons, but not M1-projecting (M1-p) neurons. Furthermore, S2-p neurons, but not M1-p neurons, became excited during spontaneous unrewarded licking in 'Good performer' mice, but not in 'Naive' mice. Thus, a learning-induced, projection-specific signal from S1 to S2 may contribute to goal-directed sensorimotor transformation of whisker sensation into licking motor output.
000221807 700__ $$0244125$$aYamashita, Takayuki$$g204148$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Lausanne, Switzerland
000221807 700__ $$0243169$$aPetersen, Carl C. H.$$g157467$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Lausanne, Switzerland
000221807 773__ $$j5$$qe15798$$tElife
000221807 8564_ $$s1785350$$uhttps://infoscience.epfl.ch/record/221807/files/e15798-download.pdf$$yPublisher's version$$zPublisher's version
000221807 909C0 $$0252149$$pLSENS$$xU10837
000221807 909CO $$ooai:infoscience.tind.io:221807$$pSV$$particle$$qGLOBAL_SET
000221807 917Z8 $$x182396
000221807 937__ $$aEPFL-ARTICLE-221807
000221807 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000221807 980__ $$aARTICLE