000221723 001__ 221723
000221723 005__ 20181203024347.0
000221723 0247_ $$2doi$$a10.1007/s00429-015-1080-1
000221723 022__ $$a1863-2653
000221723 02470 $$2ISI$$a000382684300004
000221723 037__ $$aARTICLE
000221723 245__ $$aAltered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks
000221723 260__ $$bSpringer Heidelberg$$c2016$$aHeidelberg
000221723 269__ $$a2016
000221723 300__ $$a18
000221723 336__ $$aJournal Articles
000221723 520__ $$aEpilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined alterations in sensory processing and the underlying biochemical and neuroanatomical changes in tetanus neurotoxin (TeNT)-induced focal epilepsy in mouse visual cortex. We documented persistent epileptiform electrographic discharges and upregulation of GABAergic markers at the completion of TeNT effects. We also found a significant remodeling of the dendritic arbors of pyramidal neurons, with increased dendritic length and branching, and overall reduction in spine density but significant preservation of mushroom, mature spines. Functionally, spontaneous neuronal discharge was increased, visual responses were less reliable, and electrophysiological and behavioural visual acuity was consistently impaired in TeNT-injected mice. These data demonstrate robust, long-term remodeling of both inhibitory and excitatory circuitry associated with specific disturbances of network function in neocortical epilepsy.
000221723 6531_ $$aTetanus neurotoxin
000221723 6531_ $$aVisual cortex
000221723 6531_ $$aDendritic spines
000221723 6531_ $$aSpontaneous activity
000221723 6531_ $$aVisual acuity
000221723 6531_ $$aEpilepsy
000221723 700__ $$uCNR, Neurosci Inst, Via G Moruzzi 1, I-56124 Pisa, Italy$$aVannini, Eleonora
000221723 700__ $$uCNR, Neurosci Inst, Via G Moruzzi 1, I-56124 Pisa, Italy$$aRestani, Laura
000221723 700__ $$uCNR, Neurosci Inst, Via G Moruzzi 1, I-56124 Pisa, Italy$$aPietrasanta, Marta
000221723 700__ $$uCNR, Neurosci Inst, Via G Moruzzi 1, I-56124 Pisa, Italy$$aPanarese, Alessandro
000221723 700__ $$uScuola Super Sant Anna, BioRobot Inst, Pisa, Italy$$aMazzoni, Alberto
000221723 700__ $$uUniv Padua, Dept Biomed Sci, Padua, Italy$$aRossetto, Ornella
000221723 700__ $$uCNR, Inst Cell Biol & Neurobiol, Rome, Italy$$aMiddei, Silvia
000221723 700__ $$0246201$$g218366$$uScuola Super Sant Anna, BioRobot Inst, Pisa, Italy$$aMicera, Silvestro
000221723 700__ $$aCaleo, Matteo$$uCNR, Neurosci Inst, Via G Moruzzi 1, I-56124 Pisa, Italy
000221723 773__ $$j221$$tBrain Structure & Function$$k6$$q2919-2936
000221723 909C0 $$xU12522$$0252419$$pTNE
000221723 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:221723
000221723 917Z8 $$x218366
000221723 937__ $$aEPFL-ARTICLE-221723
000221723 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000221723 980__ $$aARTICLE