Adjuvant-Loaded Subcellular Vesicles Derived From Disrupted Cancer Cells for Cancer Vaccination

Immunogenic subcellular vesicular particles that can be used to stimulate antigen-specific immune responses in vitro and in vivo are generated from whole cancer cells. The particles retain a broad antigen repertoire similar to that of the parent cells, and can be loaded with disparate adjuvant payloads. These particles may represent a superior alternative to lysate, the standard for primary antigen preparations, in various cancer vaccine applications.


Published in:
Small, 12, 17, 2321-2333
Year:
2016
Publisher:
Wiley-Blackwell
ISSN:
1613-6810
Laboratories:




 Record created 2016-08-30, last modified 2018-03-17


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