Sustained Delivery Of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Promotes Endogenous Cardiac Repair And Regeneration In The Chronic Ischemic Heart

The aim of this study was to test the sustained release of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) using an injectable supramolecular hydrogel based on ureido-pyrimidinone (UPy) moieties in order to recruit and activate endogenous porcine cardiac stem/progenitor cells (epCSCs) towards the infarct borderzone leading to increased myocardial repair in a porcine model of chronic myocardial infarction (MI).

Publié dans:
Journal of the American College of Cardiology, 61, 10, E1141
Présenté à:
62nd Annual Scientific Session of the American College of Cardiology, San Francisco, CA, March 9-11, 2013

 Notice créée le 2016-08-30, modifiée le 2019-08-12

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