Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System
Dankers, Patricia Y. W.; Hermans, Thomas M.; Baughman, Travis W.; Kamikawa, Yuko; Kieltyka, Roxanne E.; Bastings, Maartje; Janssen, Henk M.; Sommerdijk, Nico A. J. M.; Larsen, Antje; Van Luyn, Marja J. A.; Bosman, Anton W.; Popa, Eliane R.; Fytas, George; Meijer, E. W.
2012

Abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

Details

Title Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System
Author(s) Dankers, Patricia Y. W. ; Hermans, Thomas M. ; Baughman, Travis W. ; Kamikawa, Yuko ; Kieltyka, Roxanne E. ; Bastings, Maartje ; Janssen, Henk M. ; Sommerdijk, Nico A. J. M. ; Larsen, Antje ; Van Luyn, Marja J. A. ; Bosman, Anton W. ; Popa, Eliane R. ; Fytas, George ; Meijer, E. W.
Published in Advanced Materials
Volume 24
Issue 20
Pages 2703-2709
Date 2012
Publisher Wiley-Blackwell
ISSN 0935-9648
DOI https://doi.org/10.1002/adma.201104072
Laboratories PBL
Record Appears in Scientific production and competences > STI - School of Engineering > IMX - Institute of Materials > PBL - Programmable Biomaterials Laboratory
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2016-08-30

Actions