User-Friendly Image-Based Segmentation and Analysis of Chromosomes

We designed two efficient and user-friendly tools for the segmentation and analysis of images containing chromosomes or, more generally, rod-shaped elements that are spread on microscopic slides. The segmentation tool allows to automatically extract the profile of each chromosome and to sort the collection of profiles in a karyotype image. The analysis tool is interactive and allows to extract quantitative measurements and annotate the relative position of the centromere to the chromosome extremities in a fast and reproducible way. The two methods rely on custom variants of parametric active contours. Both have been designed as user-friendly plug-ins for the open-source software ImageJ.


Published in:
Proceedings of the Thirteenth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'16), Prague, Czech Republic, 395–398
Year:
2016
Publisher:
New York, IEEE
ISBN:
978-1-4799-2349-6
978-1-4799-2350-2
Keywords:
Laboratories:




 Record created 2016-08-23, last modified 2018-10-07

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