000220833 001__ 220833
000220833 005__ 20180913063829.0
000220833 020__ $$a978-0-8194-8253-2
000220833 0247_ $$2doi$$a10.1117/12.860815
000220833 037__ $$aCONF
000220833 245__ $$aOn-Chip Nanoplasmonic Biosensors with Actively Controlled Nanofluidic Surface Delivery
000220833 269__ $$a2010
000220833 260__ $$bSPIE-INT SOC OPTICAL ENGINEERING$$c2010
000220833 336__ $$aConference Papers
000220833 490__ $$aProceedings of SPIE
000220833 500__ $$aConference on Plasmonics: Metallic Nanostructures and Their Optical Properties VIII, San Diego, CA, AUG 01-05, 2010
000220833 520__ $$aPerformances of surface biosensors are often controlled by the analyte delivery rate to the sensing surface instead of sensors intrinsic detection capabilities. In a microfluidic channel, analyte transports diffusively to the biosensor surface severely limiting its performance. At low concentrations, this limitation, commonly known as mass transport problem, causes impractically long detection times extending from days to months. In this proceeding, we propose and demonstrate a hybrid biosensing platform merging nanoplasmonics and nanofluidics. Unlike conventional approaches where the analytes simply stream pass over the sensing surface, our platform enables targeted delivery of analytes to the sensing surface. Our detection platform is based on extraordinary light transmission effect (EOT) in suspended plasmonic nanohole arrays. The subwavelength size nanoholes here act as nanofluidic channels connecting the microfluidic chambers on both sides of the sensors. In order to materialize our detection platform, we also introduce a novel multilayered micro/nanofluidics scheme allowing three dimensional control of the fluidic flow. Using our platform, we show 14-fold improvement in mass transport rate constant appearing in the exponential term. To fabricate these biosensors, we also introduce a lift-off free plasmonic device fabrication technique based on positive resist electron beam lithography. Simplicity of this fabrication technique allows us to fabricate nanostructures with ease, high yield/reproducibility and minimal surface roughness. As a result, we achieve higher refractive index sensitivities. This fabrication technique can find wide range of applications in nanoplasmonics field by eliminating the need for operationally slow and expensive focused ion beam lithography.
000220833 6531_ $$abiosensors
000220833 6531_ $$aExtraordinary Light Transmission
000220833 6531_ $$aMass Transport
000220833 6531_ $$aNanohole
000220833 6531_ $$aPlasmonics
000220833 700__ $$aYanik, Ahmet Ali
000220833 700__ $$aHuang, Min
000220833 700__ $$aArtar, Alp
000220833 700__ $$aChang, Tsung-Yao
000220833 700__ $$aAltug, Hatice
000220833 7112_ $$aPLASMONICS: METALLIC NANOSTRUCTURES AND THEIR OPTICAL PROPERTIES VIII$$c1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
000220833 720_1 $$aStockman, MI$$eed.
000220833 773__ $$j7757$$tPLASMONICS: METALLIC NANOSTRUCTURES AND THEIR OPTICAL PROPERTIES VIII
000220833 909C0 $$0252567$$pBIOS$$xU12650
000220833 909CO $$ooai:infoscience.tind.io:220833$$pconf$$pSTI
000220833 937__ $$aEPFL-CONF-220833
000220833 970__ $$ayanik_-chip_2010-1/BIOS
000220833 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000220833 980__ $$aCONF