Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability
Zhang, Yanfeng; Yin, Qian; Yin, Lichen; Ma, Liang; Tang, Li; Cheng, Jianjun
2013

Abstract

Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.

Details

Title Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability
Author(s) Zhang, Yanfeng ; Yin, Qian ; Yin, Lichen ; Ma, Liang ; Tang, Li ; Cheng, Jianjun
Published in Angewandte Chemie International Edition
Volume 52
Issue 25
Pages 6435-6439
Date 2013
Publisher Wiley-Blackwell
ISSN 1433-7851
DOI https://doi.org/10.1002/anie.201300497
Laboratories LBI
Record Appears in Scientific production and competences > STI - School of Engineering > IBI-STI - Interfaculty Institute of Bioengineering > LBI - Laboratory of Biomaterials for Immunoengineering
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2016-08-15

Actions