000219908 001__ 219908
000219908 005__ 20180913063801.0
000219908 0247_ $$2doi$$a10.1016/bs.ctdb.2015.11.022
000219908 020__ $$a978-0-12-802976-3
000219908 020__ $$a978-0-12-802956-5
000219908 022__ $$a0070-2153
000219908 02470 $$2ISI$$a000376939100017
000219908 037__ $$aBOOK_CHAP
000219908 245__ $$aTopological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci
000219908 260__ $$aSan Diego$$bElsevier Academic Press Inc$$c2016
000219908 269__ $$a2016
000219908 300__ $$a19
000219908 336__ $$aBook Chapters
000219908 490__ $$aCurrent Topics in Developmental Biology$$v116
000219908 520__ $$aHox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was due to the accumulation of long-range regulations flanking Hox loci, a phenomenon made possible by the successive genome duplications that occurred at the root of the vertebrate lineage, similar to gene neofunctionalization but applied to a coordinated multigenic system. Here, we propose that the emergence of such large vertebrate regulatory landscapes containing a range of global enhancers was greatly facilitated by the presence of topologically associating domains (TADs). These chromatin domains, mostly constitutive, may have been used as genomic niches where novel regulations could evolve due to both the preexistence of a structural backbone poised to integrate novel regulatory inputs, and a highly adaptive transcriptional readout. We propose a scenario for the coevolution of such TADs and the emergence of pleiotropy at ancestral vertebrate Hox loci.
000219908 700__ $$0246963$$aDarbellay, Fabrice$$g223688$$uFed Inst Technol, Sch Life Sci, Lausanne, Switzerland
000219908 700__ $$0240276$$aDuboule, Denis$$g141236$$uFed Inst Technol, Sch Life Sci, Lausanne, Switzerland
000219908 720_1 $$aWassarman, Pm$$eed.
000219908 773__ $$j116$$q299-314$$tEssays On Developmental Biology, Pt A
000219908 8564_ $$s630539$$uhttps://infoscience.epfl.ch/record/219908/files/Topological-Domains-Metagenes-and-the-Emergence-of-Pleiotropic-Reg.pdf$$yPublisher's version$$zPublisher's version
000219908 909C0 $$0252099$$pUPDUB$$xU11705
000219908 909CO $$ooai:infoscience.tind.io:219908$$pSV$$pchapter
000219908 917Z8 $$x188186
000219908 917Z8 $$x182396
000219908 917Z8 $$x182396
000219908 937__ $$aEPFL-CHAPTER-219908
000219908 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000219908 980__ $$aCHAPTER