000219805 001__ 219805
000219805 005__ 20180913063758.0
000219805 0247_ $$2doi$$a10.1016/j.celrep.2016.03.063
000219805 022__ $$a2211-1247
000219805 02470 $$2ISI$$a000374730600004
000219805 037__ $$aARTICLE
000219805 245__ $$aParvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation
000219805 269__ $$a2016
000219805 260__ $$aCambridge$$bElsevier$$c2016
000219805 300__ $$a7
000219805 336__ $$aJournal Articles
000219805 520__ $$aSensory processing in neocortex is primarily driven by glutamatergic excitation, which is counterbalanced by GABAergic inhibition, mediated by a diversity of largely local inhibitory interneurons. Here, we trained mice to lick a reward spout in response to whisker deflection, and we recorded from genetically defined GABAergic inhibitory neurons in layer 2/3 of the primary somatosensory barrel cortex. Parvalbumin-expressing (PV), vasoactive intestinal peptide-expressing (VIP), and somatostatin-expressing (SST) neurons displayed distinct action potential firing dynamics during task performance. Whereas SST neurons fired at low rates, both PV and VIP neurons fired at high rates both spontaneously and in response to whisker stimulation. After an initial outcome-invariant early sensory response, PV neurons had lower firing rates in hit trials compared to miss trials. Optogenetic inhibition of PV neurons during this time period enhanced behavioral performance. Hence, PV neuron activity might contribute causally to gating the sensorimotor transformation of a whisker sensory stimulus into licking motor output.
000219805 700__ $$0243166$$aSachidhanandam, Shankar$$g182798$$uEcole Polytech Fed Lausanne, Fac Life Sci, Brain Mind Inst, Lab Sensory Proc, CH-1015 Lausanne, Switzerland
000219805 700__ $$aSermet, B. Semihcan$$uEcole Polytech Fed Lausanne, Fac Life Sci, Brain Mind Inst, Lab Sensory Proc, CH-1015 Lausanne, Switzerland
000219805 700__ $$0243169$$aPetersen, Carl C. H.$$g157467$$uEcole Polytech Fed Lausanne, Fac Life Sci, Brain Mind Inst, Lab Sensory Proc, CH-1015 Lausanne, Switzerland
000219805 773__ $$j15$$k4$$q700-706$$tCell Reports
000219805 8564_ $$s2484526$$uhttps://infoscience.epfl.ch/record/219805/files/1-s2.0-S2211124716303345-main.pdf$$yPublisher's version$$zPublisher's version
000219805 909C0 $$0252149$$pLSENS$$xU10837
000219805 909CO $$ooai:infoscience.tind.io:219805$$pSV$$particle
000219805 917Z8 $$x182396
000219805 937__ $$aEPFL-ARTICLE-219805
000219805 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000219805 980__ $$aARTICLE