000219765 001__ 219765
000219765 005__ 20181203024310.0
000219765 0247_ $$2doi$$a10.1016/j.jmr.2016.03.004
000219765 022__ $$a1090-7807
000219765 02470 $$2ISI$$a000375510100005
000219765 037__ $$aARTICLE
000219765 245__ $$aA low-power high-sensitivity single-chip receiver for NMR microscopy
000219765 260__ $$aSan Diego$$bAcademic Press Inc Elsevier Science$$c2016
000219765 269__ $$a2016
000219765 300__ $$a10
000219765 336__ $$aJournal Articles
000219765 520__ $$aIn this paper, we present a fully-integrated receiver for NMR microscopy applications manufactured in a 0.13 mu m CMOS technology. The design co-integrates a 10-turn planar detection coil together with a complete quadrature, low-IF downconversion receiver on a single chip, which operates from a single 1.5 V supply with a total power dissipation of 18 mW. The detector's measured time-domain spin sensitivity is 3 x 10(13) H-1 spins/root Hz at 7 T. Additionally, the paper discusses two important aspects of NMR microscopy using planar detection coils: the link between the detection coil's spin sensitivity and the achievable image SNR and the correction of image artifacts induced by the inhomogeneous sensitivity profile of planar detection coils. More specifically, we derive analytical expressions for both the theoretical image SNR as a function of the coil's spin sensitivity and the sensitivity correction for a known coil sensitivity profile in CTI MR imaging experiments. Both expressions are validated using measured data in the imaging section of the paper. Thanks to the improved spin sensitivity of the utilized integrated receiver chip compared to a previously presented design, we were able to obtain sensitivity corrected images in a 7 T spectroscopy magnet with isotropic resolutions of 9.6 mu m and 5 mu m with single-shot SNRs of 37 and 15 in relatively short imaging times of 4.4 h and 24 h, respectively. (C) 2016 Elsevier Inc. All rights reserved.
000219765 6531_ $$aMRI
000219765 6531_ $$aMicro-MRI
000219765 6531_ $$aNMR microscopy
000219765 6531_ $$aIntegrated circuits
000219765 6531_ $$aCMOS
000219765 6531_ $$aPlanar microcoils
000219765 6531_ $$aSensitivity correction
000219765 6531_ $$aSignal-to-noise ratio
000219765 700__ $$aAnders, Jens$$uUniv Ulm, Inst Microelect, Albert Einstein Allee 43, D-89081 Ulm, Germany
000219765 700__ $$aHandwerker, Jonas$$uUniv Ulm, Inst Microelect, Albert Einstein Allee 43, D-89081 Ulm, Germany
000219765 700__ $$aOrtmanns, Maurits$$uUniv Ulm, Inst Microelect, Albert Einstein Allee 43, D-89081 Ulm, Germany
000219765 700__ $$0240034$$aBoero, Giovanni$$g110635
000219765 773__ $$j266$$q41-50$$tJournal Of Magnetic Resonance
000219765 909C0 $$0252040$$pLMIS1$$xU10321
000219765 909CO $$ooai:infoscience.tind.io:219765$$pSTI$$particle
000219765 917Z8 $$x144315
000219765 937__ $$aEPFL-ARTICLE-219765
000219765 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000219765 980__ $$aARTICLE