High-field dissolution dynamic nuclear polarization of [1-C-13]pyruvic acid

[1-C-13]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-C-13] pyruvic acid, unextrapolated solution-state C-13 polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.


Published in:
Physical Chemistry Chemical Physics, 18, 18, 12409-12413
Year:
2016
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
1463-9076
Laboratories:




 Record created 2016-07-19, last modified 2018-03-17


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