000219422 001__ 219422
000219422 005__ 20180317092936.0
000219422 0247_ $$2doi$$a10.7554/eLife.09148
000219422 02470 $$2ISI$$a000371892700001
000219422 037__ $$aARTICLE
000219422 245__ $$aIntraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans
000219422 269__ $$a2016
000219422 260__ $$aCambridge$$bElife Sciences Publications Ltd$$c2016
000219422 300__ $$a27
000219422 336__ $$aJournal Articles
000219422 520__ $$aRestoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents. The MNT process was used to modulate the temporal pattern of electrical spikes delivered to the human median nerve via percutaneous microstimulation in four intact subjects and via implanted intrafascicular stimulation in one transradial amputee. Both approaches allowed the subjects to reliably discriminate spatial coarseness of surfaces as confirmed also by a hybrid neural model of the median nerve. Moreover, MNT-evoked EEG activity showed physiologically plausible responses that were superimposable in time and topography to the ones elicited by a natural mechanical tactile stimulation. These findings can open up novel opportunities for sensory restoration in the next generation of neuro-prosthetic hands.
000219422 700__ $$aOddo, Calogero Maria$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$0246240$$aRaspopovic, Stanisa$$g221044$$uUniv Campus Biomed Roma, Lab Biomed Robot & Biomicrosyst, Rome, Italy
000219422 700__ $$0249777$$aArtoni, Fiorenzo$$g268982$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$aMazzoni, Alberto$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$aSpigler, Giacomo$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$0248048$$aPetrini, Francesco$$g240517$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Bertarelli Fdn Chair Translat NeuroEngn, Lausanne, Switzerland
000219422 700__ $$aGiambattistelli, Federica$$uUniv Campus Biomed Roma, Inst Neurol, Rome, Italy
000219422 700__ $$aVecchio, Fabrizio$$uIRCCS San Raffaele Pisana, Brain Connect Lab, Rome, Italy
000219422 700__ $$aMiraglia, Francesca$$uIRCCS San Raffaele Pisana, Brain Connect Lab, Rome, Italy
000219422 700__ $$aZollo, Loredana$$uUniv Campus Biomed Roma, Lab Biomed Robot & Biomicrosyst, Rome, Italy
000219422 700__ $$aDi Pino, Giovanni$$uUniv Campus Biomed Roma, Lab Biomed Robot & Biomicrosyst, Rome, Italy
000219422 700__ $$aCamboni, Domenico$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$aCarrozza, Maria Chiara$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 700__ $$aGuglielmelli, Eugenio$$uUniv Campus Biomed Roma, Lab Biomed Robot & Biomicrosyst, Rome, Italy
000219422 700__ $$aRossini, Paolo Maria$$uIRCCS San Raffaele Pisana, Brain Connect Lab, Rome, Italy
000219422 700__ $$aFaraguna, Ugo$$uAzienda Osped Univ Pisa, Pisa, Italy
000219422 700__ $$0246201$$aMicera, Silvestro$$g218366$$uScuola Superiore St Anna, BioRobot Inst, Pisa, Italy
000219422 773__ $$j5$$qe09148$$teLIFE
000219422 909CO $$ooai:infoscience.tind.io:219422$$particle$$pSTI
000219422 909C0 $$0252419$$pTNE$$xU12522
000219422 917Z8 $$x218366
000219422 937__ $$aEPFL-ARTICLE-219422
000219422 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000219422 980__ $$aARTICLE