000217783 001__ 217783
000217783 005__ 20190317000421.0
000217783 0247_ $$2doi$$a10.1111/ejn.13080
000217783 022__ $$a0953-816X
000217783 02470 $$2ISI$$a000369764500017
000217783 037__ $$aARTICLE
000217783 245__ $$aA regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals
000217783 269__ $$a2016
000217783 260__ $$bWiley-Blackwell$$c2016$$aHoboken
000217783 300__ $$a12
000217783 336__ $$aJournal Articles
000217783 520__ $$aDespite significant advances in robotics, commercially advanced prosthetics provide only a small fraction of the functionality of the amputated limb that they are meant to replace. Peripheral nerve interfacing could provide a rich controlling link between the body and these advanced prosthetics in order to increase their overall utility. Here, we report on the development of a fully integrated regenerative microchannel interface with 30 microelectrodes and signal extraction capabilities enabling evaluation in an awake and ambulatory rat animal model. In vitro functional testing validated the capability of the microelectrodes to record neural signals similar in size and nature to those that occur invivo. In vitro dorsal root ganglia cultures revealed striking cytocompatibility of the microchannel interface. Finally, invivo, the microchannel interface was successfully used to record a multitude of single-unit action potentials through 63% of the integrated microelectrodes at the early time point of 3weeks. This marks a significant advance in microchannel interfacing, demonstrating the capability of microchannels to be used for peripheral nerve interfacing.
000217783 6531_ $$anerve conduction
000217783 6531_ $$anerve injury and regeneration
000217783 6531_ $$aneural interfacing
000217783 6531_ $$aneural recordings
000217783 6531_ $$aregenerative neural interface
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aSrinivasan, Akhil
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aTipton, John
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aTahilramani, Mayank
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aKharbouch, Adel
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aGaupp, Eric
000217783 700__ $$uEmory Univ, Sch Med, 313 Ferst Dr, Atlanta, GA 30332 USA$$aSong, Chao
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aVenkataraman, Poornima
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aFalcone, Jessica
000217783 700__ $$0246296$$g208625$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Microengn, Ctr Neuroprosthet, CH-1015 Lausanne, Switzerland$$aLacour, Stephanie P.
000217783 700__ $$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA$$aStanley, Garrett B.
000217783 700__ $$aEnglish, Arthur W.
000217783 700__ $$aBellamkonda, Ravi V.$$uGeorgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 313 Ferst Dr, Atlanta, GA 30332 USA
000217783 773__ $$j43$$tEuropean Journal Of Neuroscience$$k3$$q474-485
000217783 8564_ $$uhttps://infoscience.epfl.ch/record/217783/files/EuropJNeuroscience%202015.pdf$$zn/a$$s2959325$$yn/a
000217783 909C0 $$xU12393$$0252424$$pLSBI
000217783 909CO $$qGLOBAL_SET$$pSTI$$ooai:infoscience.tind.io:217783$$particle
000217783 917Z8 $$x208625
000217783 937__ $$aEPFL-ARTICLE-217783
000217783 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000217783 980__ $$aARTICLE