The use of multi-core clusters is a promising option for data-intensive embedded applications such as multi-modal sensor fusion, image understanding, mobile augmented reality. In this paper, we propose a power-efficient 3-D on-chip interconnect for multi-core clusters with stacked L2 cache memory. A new switch design makes a circuit-switched Mesh-of-Tree (MoT) interconnect reconfigurable to support power-gating of processing cores, memory blocks, and unnecessary interconnect resources (routing switch, arbitration switch, inverters placed along the on-chip wires). The proposed 3-D MoT improves the power efficiency up to 77% in terms of energy-delay product (EDP).