000217082 001__ 217082
000217082 005__ 20190317000415.0
000217082 0247_ $$2doi$$a10.1007/s12668-016-0196-y
000217082 02470 $$2ISI$$a000384891600001
000217082 037__ $$aARTICLE
000217082 245__ $$aAn Innovative System of Membranes for the Monitoring of Endogenous and Exogenous Metabolites
000217082 269__ $$a2016
000217082 260__ $$bSpringer$$c2016$$aNew York
000217082 300__ $$a8
000217082 336__ $$aJournal Articles
000217082 520__ $$aThe development of a low-cost, robust, and versatile biosensors for the rapid detection of endogenous and exogenous metabolites in small animals is of great interest for health-care, pharmaceuticals, and in translational medicine. This work presents a complete in vitro characterization of a system of membranes for the development of a biosensor that will be integrated with the dedicated electronics into an implantable device for small animals. The system of membrane consists of an “inner” permselective layer, designed to filter the signal generated by the oxidation of interfering substances present in biological fluids; an “outer” layer made by an epoxy-enhanced polyurethane film, that regulates the passage of glucose and oxygen to the electrode surface and provides a biocompatible layer for a correct integration with the surrounding tissue. This system of membrane is employed in a glucose sensor that successfully monitors glucose in both the human and mouse physiological range, in PBS and in human serum at 37 ◦C. The sensor showed good stability for 30 days, and the permselective membrane effectively filtered out ascorbic acid and uric acid. Moreover, with the same system of membrane, we developed a biosensor for detection of the anti-inflammatory drug acetaminophen. The integration with the dedicated electronics is successfully used to measure glucose in the physiological range.
000217082 6531_ $$abiosensor
000217082 6531_ $$apermselective membrane
000217082 6531_ $$aanalyte-diffusion membrane
000217082 6531_ $$aimplantable
000217082 6531_ $$ainterferences
000217082 700__ $$0245318$$g198938$$aBaj-Rossi, Camilla
000217082 700__ $$aGhoreishizadeh, Sara
000217082 700__ $$0242413$$g182237$$aCarrara, Sandro
000217082 700__ $$aDe Micheli, Giovanni$$g167918$$0240269
000217082 773__ $$j6$$tBioNanoScience$$k2$$q85-92
000217082 8564_ $$uhttps://infoscience.epfl.ch/record/217082/files/art3A10.10072Fs12668-016-0196-y.pdf$$zn/a$$s853429$$yn/a
000217082 909C0 $$xU11140$$0252283$$pLSI1
000217082 909CO $$particle$$ooai:infoscience.tind.io:217082$$qGLOBAL_SET$$pSTI$$pIC
000217082 917Z8 $$x112915
000217082 917Z8 $$x112915
000217082 917Z8 $$x112915
000217082 937__ $$aEPFL-ARTICLE-217082
000217082 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000217082 980__ $$aARTICLE