000216413 001__ 216413
000216413 005__ 20180913063600.0
000216413 0247_ $$2doi$$a10.3389/fncel.2015.00468
000216413 022__ $$a1662-5102
000216413 02470 $$2ISI$$a000366589000001
000216413 037__ $$aARTICLE
000216413 245__ $$aA New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
000216413 260__ $$aLausanne$$bFrontiers Media Sa$$c2015
000216413 269__ $$a2015
000216413 300__ $$a20
000216413 336__ $$aReviews
000216413 520__ $$aMental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.
000216413 6531_ $$apsychiatric disorder
000216413 6531_ $$aglia
000216413 6531_ $$aastrocyte
000216413 6531_ $$aoligodendrocyte
000216413 6531_ $$amicroglia
000216413 6531_ $$aNG2 glia
000216413 6531_ $$amood
000216413 6531_ $$acognition
000216413 700__ $$aElsayed, Maha$$uEcole Polytech Fed Lausanne, Brain Mind Inst, Lab Neuroenerget & Cellular Dynam, Lausanne, Switzerland
000216413 700__ $$0243698$$aMagistretti, Pierre J.$$g134990$$uEcole Polytech Fed Lausanne, Brain Mind Inst, Lab Neuroenerget & Cellular Dynam, Lausanne, Switzerland
000216413 773__ $$j9$$q468$$tFrontiers In Cellular Neuroscience
000216413 909C0 $$0252265$$pLNDC$$xU11150
000216413 909CO $$ooai:infoscience.tind.io:216413$$pSV$$preview
000216413 917Z8 $$x219572
000216413 937__ $$aEPFL-REVIEW-216413
000216413 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000216413 980__ $$aREVIEW