000216200 001__ 216200
000216200 005__ 20180913063555.0
000216200 0247_ $$2doi$$a10.1039/c5cc06983a
000216200 022__ $$a1359-7345
000216200 02470 $$2ISI$$a000364819600008
000216200 037__ $$aARTICLE
000216200 245__ $$aNanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro
000216200 260__ $$aCambridge$$bRoyal Soc Chemistry$$c2015
000216200 269__ $$a2015
000216200 300__ $$a4
000216200 336__ $$aJournal Articles
000216200 520__ $$aThe in vitro inter-and intra-cellular distribution of an isotopically labelled ruthenium(II)-arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS). Ultra-high resolution isotopic images of C-13, N-15, and Ru indicate that the phosphine ligand remains coordinated to the ruthenium(II) ion whereas the arene detaches. The complex localizes mainly on the membrane or at the interface between cells which correlates with its anti-metastatic effects.
000216200 700__ $$aLee, Ronald F. S.$$uEcole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland
000216200 700__ $$aEscrig, Stephane$$uEcole Polytech Fed Lausanne, Lab Biol Geochem, CH-1015 Lausanne, Switzerland
000216200 700__ $$aCroisier, Marie$$uEcole Polytech Fed Lausanne, Interdisciplinary Ctr Electron Microscopy, CH-1015 Lausanne, Switzerland
000216200 700__ $$aClerc-Rosset, Stephanie$$uEcole Polytech Fed Lausanne, Interdisciplinary Ctr Electron Microscopy, CH-1015 Lausanne, Switzerland
000216200 700__ $$0240043$$aKnott, Graham W.$$g159872$$uEcole Polytech Fed Lausanne, Interdisciplinary Ctr Electron Microscopy, CH-1015 Lausanne, Switzerland
000216200 700__ $$aMeibom, Anders$$uEcole Polytech Fed Lausanne, Lab Biol Geochem, CH-1015 Lausanne, Switzerland
000216200 700__ $$aDavey, Curt A.
000216200 700__ $$aJohnsson, Kai$$uEcole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland
000216200 700__ $$aDyson, Paul J.$$uEcole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland
000216200 773__ $$j51$$k92$$q16486-16489$$tChemical Communications
000216200 909C0 $$0252025$$pCIME$$xU10192
000216200 909C0 $$0252027$$pLIP$$xU10102
000216200 909CO $$ooai:infoscience.tind.io:216200$$pSB$$particle
000216200 917Z8 $$x178548
000216200 937__ $$aEPFL-ARTICLE-216200
000216200 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000216200 980__ $$aARTICLE
000216200 981__ $$a212767