Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach
Santi, Sara; Barakat, Elsie; Neier, Reinhard; Herzig, Hans Peter
2015

Abstract

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid beta-peptides (A beta), linked to Alzheimer's Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the A beta aggregates, throughout fibrillization.

Details

Title Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach
Author(s) Santi, Sara ; Barakat, Elsie ; Neier, Reinhard ; Herzig, Hans Peter
Published in Biosensing And Nanomedicine Viii
Pagination 3
Editor(s)
Series Proceedings of SPIE
Volume 9550
Pages 95500V
Conference Conference on Biosensing and Nanomedicine VIII, San Diego, CA, AUG 09-12, 2015
Date 2015
Publisher Bellingham, Spie-Int Soc Optical Engineering
ISSN 0277-786X
ISBN 978-1-62841-716-6
Keywords
DOI https://doi.org/10.1117/12.2188595
Other identifier(s) View record in Web of Science
Laboratories OPT
Record Appears in Scientific production and competences > STI - School of Engineering > STI Archives > OPT - Optics and Photonics Technology Laboratory
Peer-reviewed publications
Conference Papers
Work produced at EPFL
Published
Record creation date 2016-02-16

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