Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid beta-peptides (A beta), linked to Alzheimer's Disease. Here, we demonstrate the efficacy of the BSW sensor by describing a simultaneous light scattering measurement, with the purpose of real-time monitoring the size change of the A beta aggregates, throughout fibrillization.


Editor(s):
Mohseni, H
Agahi, Mh
Razeghi, M
Published in:
Biosensing And Nanomedicine Viii, 9550, 95500V
Presented at:
Conference on Biosensing and Nanomedicine VIII, San Diego, CA, AUG 09-12, 2015
Year:
2015
Publisher:
Bellingham, Spie-Int Soc Optical Engineering
ISSN:
0277-786X
ISBN:
978-1-62841-716-6
Keywords:
Laboratories:




 Record created 2016-02-16, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)