From Dimethylamine to Pyrrolidine: The Development of an Improved Nickel Pincer Complex for Cross-Coupling of Nonactivated Secondary Alkyl Halides

Replacement of a dimethyl amino group of the amidobis(amine) nickel(II) pincer complex (1), [((N2N)-N-Me)-Ni-Cl], by a pyrrolidino group resulted in a new nickel(II) pincer complex (2), [((PNNN)-N-yr-N-Me)Ni-Cl]. Complex 2 is an efficient catalyst for Kumada and Suzuki-Miyaura cross-coupling of nonactivated secondary alkyl halides, while complex 1 is largely inactive. The significant activity difference is tentatively attributed to a minimal structural difference, which leads to a more hemilabile ligand.


Published in:
ACS Catalysis, 6, 1, 258-261
Year:
2016
Publisher:
Washington, American Chemical Society
ISSN:
2155-5435
Keywords:
Laboratories:




 Record created 2016-01-22, last modified 2018-03-17

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Pyrrolidine_ACS_SI-rev-hu1 - Download fulltextPDF
Pyrrolidine_ACS-rev-Hu1 - Download fulltextPDF
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