Currently, energy efficiency in buildings is a primary objective of energy policy at regional, national and international levels. On a local scale, this trend has been detected also in Switzerland, where almost 40% of energy consumption has been assumed to be used for heating, ventilation and lighting in buildings. The smart living lab project is born under this scenario, aiming to be a building icon and a sustainability example. Via reducing environmental impacts and its footprint on the local ecosystem, the project intends to reach certain authoritative objectives, like the ones given by the 2000 Watt-Society. The smart living lab is a research centre on future built environment in Fribourg, Switzerland. It accommodates interdisciplinary and inter-institutional research groups and provides infrastructures for experiment on developing innovative concepts and technologies related to inhabitation and work environment. The purpose of this thesis is to identify the main technical and architectural macroparameters and their contribution to energy consumption. The latter in the smart living building is calculated in the aspects of both quantity [kWh/m2] and quality [kg CO2/kWh]. Global sensitivity analysis (SA) was selected as the method to demonstrate the contribution of certain key design parameters to the building energy consumption and their correlations along with the changes of variables. Several energy simulations have been conducted with the variation of each design parameter independently. Finally, due to the elaborated cases, the SA was completed with the identification of the predominant factors on the main energy outputs e.g. primary energy.