000214474 001__ 214474
000214474 005__ 20190317000336.0
000214474 0247_ $$2doi$$a10.3390/mi6121465
000214474 022__ $$a2072-666X
000214474 02470 $$2ISI$$a000367532600008
000214474 037__ $$aARTICLE
000214474 245__ $$aA Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research
000214474 269__ $$a2015
000214474 260__ $$bMDPI$$c2015
000214474 336__ $$aJournal Articles
000214474 520__ $$aPolydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these two materials for their combined use in innovative integrated microsystems. In this paper; we attempt to investigate the aminosilane-mediated irreversible bonding method for PDMS and SU-8 with X-Ray Photoelectron Spectroscopy (XPS) surface analysis and bonding strength tests. Additionally; the selected bonding method was applied in fabricating a microelectrode array (MEA) device, including microfluidic features, which allows electrophysiological observations on compartmentalized neuronal cultures. As there is a growing trend towards microfluidic devices for neuroscience research, this type of integrated microdevice, which can observe functional alterations on compartmentalized neuronal culture, can potentially be used for neurodegenerative disease research and pharmaceutical development.
000214474 6531_ $$aPDMS
000214474 6531_ $$aSU-8
000214474 6531_ $$abonding technology
000214474 6531_ $$asurface silanization
000214474 6531_ $$aXPS analysis
000214474 6531_ $$atensile strength test
000214474 6531_ $$aintegrated microfluidic-MEA device
000214474 6531_ $$acompartmentalised neural cell culture
000214474 6531_ $$aneural activity recording
000214474 700__ $$0245911$$aRen, Yufei$$g200339
000214474 700__ $$aHuang, Shun-Ho
000214474 700__ $$0245612$$aMosser, Sébastien$$g207107
000214474 700__ $$aHeuschkel, Marc
000214474 700__ $$0240202$$aBertsch, Arnaud$$g113143
000214474 700__ $$0244196$$aFraering, Patrick$$g171915
000214474 700__ $$aChen, Jia-Jin
000214474 700__ $$0240219$$aRenaud, Philippe$$g107144
000214474 773__ $$j6$$k12$$q1923-1934$$tMicromachines
000214474 8564_ $$s2693289$$uhttps://infoscience.epfl.ch/record/214474/files/micromachines-06-01465-2.pdf$$yPublisher's version$$zPublisher's version
000214474 909C0 $$0252064$$pLMIS4$$xU10324
000214474 909C0 $$0252048$$pCMSN$$xU11281
000214474 909CO $$ooai:infoscience.tind.io:214474$$pSTI$$particle$$qGLOBAL_SET
000214474 917Z8 $$x113143
000214474 937__ $$aEPFL-ARTICLE-214474
000214474 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000214474 980__ $$aARTICLE