000214364 001__ 214364
000214364 005__ 20180913063452.0
000214364 037__ $$aARTICLE
000214364 245__ $$aCoordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes
000214364 269__ $$a1987
000214364 260__ $$c1987
000214364 336__ $$aJournal Articles
000214364 520__ $$aThe expression of p53 has been evaluated during oncogenesis of the pancreatic beta cells in transgenic mice harboring hybrid insulin-SV40 T antigen genes. Significant levels of p53 are detected in all cells expressing large T antigen. In contrast, the protein is undetectable in normal beta cells. There is a complete correspondence between the onset of expression of T antigen and the appearance of the endogenous p53 protein. In tumors, the two proteins are found in a complex. In addition, free uncomplexed T antigen is detected in every cell which expresses the transgene. These results are consistent with the participation of p53 in T antigen-induced tumorigenesis in vivo. The early appearance of p53 in all beta cells expressing large T cannot readily explain the progression of a small fraction of these cells into solid tumors.
000214364 700__ $$aEfrat, S
000214364 700__ $$aBaekkeskov, S
000214364 700__ $$aLane, D
000214364 700__ $$aHanahan, D
000214364 773__ $$j6$$k9$$q2699$$tThe EMBO Journal
000214364 8564_ $$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC553692/pdf/emboj00249-0190.pdf$$zURL
000214364 909C0 $$0252549$$pGR-STBA$$xU12906
000214364 909CO $$ooai:infoscience.tind.io:214364$$pSV$$particle
000214364 917Z8 $$x192523
000214364 917Z8 $$x192523
000214364 917Z8 $$x192523
000214364 937__ $$aEPFL-ARTICLE-214364
000214364 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000214364 980__ $$aARTICLE