Chiral Cyclopentadienyl Iridium(III) Complexes Promote Enantioselective Cycloisomerizations Giving Fused Cyclopropanes

The cyclopentadienyl (Cp) group is a very important ligand for many transition-metal complexes which have been applied in catalysis. The availability of chiral cyclopentadienyl ligands (Cp-x) lags behind other ligand classes, thus hampering the investigation of enantioselective processes. We report a library of chiral (CpIrIII)-Ir-x complexes equipped with an atropchiral Cp scaffold. A robust complexation procedure reliably provides (CpIrIII)-Ir-x complexes with tunable counterions. In a proof-of-concept application, the iodide-bearing members are shown to be highly selective for enyne cycloisomerization reactions. The dehydropiperidine-fused cyclopropane products are formed in good yields and enantioselectivities.


Published in:
Angewandte Chemie-International Edition, 54, 41, 12149-12152
Year:
2015
Publisher:
Weinheim, Wiley-V C H Verlag Gmbh
ISSN:
1433-7851
Keywords:
Laboratories:




 Record created 2015-12-02, last modified 2018-03-17


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