Chiral Cationic (CpRu)-Ru-x(II) Complexes for Enantioselective Yne-Enone Cyclizations

The cydopentadienyl (Cp) group is a ligand of great importance for many transition-metal complexes used in catalysis. Cationic CpRuII complexes with three free coordination sites are highly versatile catalysts for many atom-economic transformations. We report the synthesis of a family of (CpRuII)-Ru-x complexes with chiral Cp ligands keeping the maximum number of available coordination sites. The cationic members are efficient and selective catalysts for yne-enone cyclizations via formal hetero-Diels-Alder reactions. The transformation proceeds in <1 h at -20 degrees C and provides pyrans in up to 99:1 er. Unsaturated ester or Weinrebamide substrates directly yield the iridoid skeleton.


Published in:
Journal Of The American Chemical Society, 137, 39, 12478-12481
Year:
2015
Publisher:
Washington, American Chemical Society
ISSN:
0002-7863
Laboratories:




 Record created 2015-12-02, last modified 2018-09-13


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