Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies
Gupta, Gajendra; Nowak-Sliwinska, Patrycja; Herrero, Noelia; Dyson, Paul J.; Therrien, Bruno
2015

Abstract

A series of arene ruthenium metalla-rectangles of general formula [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)](CF3SO3)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver triflate and several linear ditopic N-ligands (N boolean AND N); pyrazine (prz), 4,4'-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4'-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The anti-proliferative activity of these multinuclear arene ruthenium metalla-rectangles was evaluated in vitro on the human ovarian cancer cells A2780 and A2780cisR and on the noncancerous cell line HEK-293. Among these complexes, two rectangles, [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-bpy)(2)](CF3SO3)(4) and [(eta(6)-p-cymene) Ru-4(4)(mu(4)-embelin)(2)(mu(2)-bpo)(2)](CF3SO3)(4), display excellent activity and selectivity for cancer cells. (C) 2015 Elsevier B.V. All rights reserved.

Details

Title Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies
Author(s) Gupta, Gajendra ; Nowak-Sliwinska, Patrycja ; Herrero, Noelia ; Dyson, Paul J. ; Therrien, Bruno
Published in Journal Of Organometallic Chemistry
Pagination 6
Volume 796
Pages 59-64
Date 2015
Publisher Lausanne, Elsevier Science Sa
ISSN 0022-328X
Keywords
DOI https://doi.org/10.1016/j.jorganchem.2015.02.004
Other identifier(s) View record in Web of Science
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2015-12-02

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