000213799 001__ 213799
000213799 005__ 20190317000330.0
000213799 037__ $$aPOST_TALK
000213799 245__ $$aElectrophysiological imaging of epileptic brain slices reveals pharmacologically confined functional changes
000213799 269__ $$a2012
000213799 260__ $$c2012
000213799 336__ $$aPosters
000213799 520__ $$aMicroelectrode arrays (MEAs) are employed to study extracellular electrical activity in neuronal tissues. Neverthe- less, commercially available MEAs provide a limited number of recording sites and do not allow a precise identifi- cation of the spatio-temporal characterization of the recorded signal. To overcome this limitation, high density MEAs, based on CMOS technology, were recently developed and validated on dissociated preparations (Ber- dondini et al. 2009). We show the platform capability to record extracellular electrophysiological signal from 4096 electrodes arranged in a squared area of 2.7 mm x 2.7 mm with inter-electrode distance of 21 μm at a sampling rate of 7.7 kHz/electrode. Here, we demonstrate the performances of these platforms for the acquisition chemi- cally evoked epileptiform activity from brain slices. Moreover the high spatial resolutions allow us to estimate the effect of drugs in spatially modulating Inter-Ictal ((I-IC) activity.
000213799 700__ $$aFerrea, Enrico
000213799 700__ $$aMedrihan, Lucian
000213799 700__ $$0249241$$g254787$$aGhezzi, Diego
000213799 700__ $$aNieus, Thierry
000213799 700__ $$aBaldelli, Pietro
000213799 700__ $$aBenfenati, Fabio
000213799 700__ $$aMaccione, Alessandro
000213799 7112_ $$dJuly 10-13, 2012$$cReutlingen, Germany$$a8th International Meeting on Substrate-Integrated Microelectrode Arrays (SIMEA)
000213799 773__ $$tProceedings of the 8th International Meeting on Substrate-Integrated Microelectrode Arrays
000213799 8564_ $$uhttps://infoscience.epfl.ch/record/213799/files/Proceedings%20of%20SIMEA%202012.pdf$$zPublisher's version$$s452212$$yPublisher's version
000213799 909C0 $$xU13047$$0252540$$pLNE
000213799 909CO $$qGLOBAL_SET$$pSTI$$ooai:infoscience.tind.io:213799$$pposter
000213799 917Z8 $$x254787
000213799 937__ $$aEPFL-POSTER-213799
000213799 973__ $$rNON-REVIEWED$$sPUBLISHED$$aOTHER
000213799 980__ $$aPOSTER