000213782 001__ 213782
000213782 005__ 20180913063435.0
000213782 037__ $$aPOST_TALK
000213782 245__ $$aA hybrid bio-organic interface for neuronal photo-activation
000213782 269__ $$a2011
000213782 260__ $$c2011
000213782 336__ $$aPosters
000213782 520__ $$aInterfacing artificial functional materials and living neuronal tissues is at the forefront of bio-nanotechnology. Attempts so far have been based on microscope processing of metals, inorganic semiconductors as electrodes or photoactive layers in biased devices, and more recently, nano-materials have been investigated. However, in spite of extensive research, the communication between biological tissues and artificial sensors is still a challenge. Constraints exist in the complexity of the fabrication processes and the mechanical properties of the implanted sensing/recording elements (poor flexibility and biocompatibility) that could elicit deleterious tissue reactions such as inflammation and gliosis. In addition, electrodes have fixed geometries that limit the location in space of the stimulus, and electrical currents are often detrimental to the overall system. In this respect, organic soft matter has potential in terms of flexibility, favorable mechanical properties and biological affinity. The use of semiconducting polymers has been reported in mechanical actuators for precise delivery of neurotransmitters, and in biosensors, such as pH and glucose sensors, where their ability to support mixed ionic/electronic charge transport was fully exploited. Conversely, organic polymers have been tested as coatings of conventional electrodes in direct neuronal interfaces for recording and stimulating neuronal activity, whereas the exploitation of their appealing optoelectronic features has never been considered for neuronal communication and photo-manipulation devices. Here, we document a new communication protocol between organic semiconductors and neuronal cells, showing photo-stimulation of neuronal activity. We report the functional interfacing of an organic semiconductor with a network of cultured primary neurons and successfully demonstrate the physiological stimulation of neuronal cells in a network by shaping visible light pulses at the polymer/electrolyte interface. In contrast with metal or silicon interfaces, our approach works without any externally applied electric field and with minimal heat dissipation, favorably addressing the thermal issues, which are extremely relevant in an efficient biological interface. Moreover, the use of soft matter provides some advantages in terms of mechanical properties, since it enables the fabrication of light, thin and flexible devices, better suited to interaction with a biological environment. In perspective, this new approach to the optical stimulation of neurons may stimulate further work towards the development of an artificial retina based on organic materials.
000213782 700__ $$0249241$$aGhezzi, Diego$$g254787
000213782 700__ $$aAntognazza, Maria Rosa
000213782 700__ $$aDal Maschio, Marco
000213782 700__ $$aLanzarini, Erica
000213782 700__ $$aLanzani, Guglielmo
000213782 700__ $$aBenfenati, Fabio
000213782 7112_ $$aNearoscience 2011 (SFN)$$cWashington, District of Columbia, USA$$dNovember 12-16, 2011
000213782 773__ $$tAbstracts of the 41th Society for Neuroscience Annual Meeting
000213782 8564_ $$s99745$$uhttps://infoscience.epfl.ch/record/213782/files/Proceedings%20of%20SFN%202011a.pdf$$yAbstract$$zAbstract
000213782 909C0 $$0252540$$pLNE$$xU13047
000213782 909CO $$ooai:infoscience.tind.io:213782$$pSTI$$pposter
000213782 917Z8 $$x254787
000213782 937__ $$aEPFL-POSTER-213782
000213782 973__ $$aOTHER$$rNON-REVIEWED$$sPUBLISHED
000213782 980__ $$aPOSTER