000213769 001__ 213769
000213769 005__ 20190317000330.0
000213769 0247_ $$2doi$$a10.1016/j.euroneuro.2015.11.017
000213769 02470 $$2ISI$$a000371844200018
000213769 037__ $$aARTICLE
000213769 245__ $$aEffects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum
000213769 269__ $$a2016
000213769 260__ $$aAmsterdam$$bElsevier Science Bv$$c2016
000213769 300__ $$a11
000213769 336__ $$aJournal Articles
000213769 520__ $$aEarly-life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males and females, as well as increased aggression against females in their male offspring. Here, we investigated whether paternal (pS) and individual (iS) exposure to peripubertal stress may exert additive effects on the long-term programming of anxiety-like and aggressive behaviors in rats. Given the key role of the lateral septum (LS) in the regulation of anxiety and aggressive behaviors and the hypothesized alterations in balance between neural excitation and inhibition in aggression-related disorders, markers for these processes were examined in the LS. Peripubertal stress was applied both in naïve male rats and in the offspring of peripubertally stressed males, and anxiety-like and aggressive behaviors were assessed at adulthood. Proton magnetic resonance spectroscopy at 6-months, and post-mortem analysis of glutamic acid decarboxylase 67 (GAD67) at 12-months were conducted in LS. We confirmed that aggressive behavior was increased by pS and iS, while only iS increased anxiety-like behavior. Individual stress led to reduced GABA, confirmed by reduced GAD67 immunolabelling, and increased glutamate, N-acetyl-aspartate, phosphocholine and creatine; while pS specifically led to reduced phosphocreatine. pS and iS do not interact and exert a differential impact on the analyzed aspects of brain function and anxiety-like behaviors. These data support the view that early-life stress can affect the behavioral and neurodevelopmental trajectories of individuals and their offspring, which may involve different neurobiological mechanisms.
000213769 6531_ $$aPuberty stress
000213769 6531_ $$aPaternal stress
000213769 6531_ $$aMetabolites
000213769 6531_ $$aLateral septum
000213769 6531_ $$aAggressive behavior
000213769 6531_ $$aAnxiety
000213769 6531_ $$aCIBM-AIT
000213769 700__ $$aCordero, M. Isabel
000213769 700__ $$0243727$$aJust, Nathalie$$g174562
000213769 700__ $$aPoirier, Guillaume L.
000213769 700__ $$0243016$$aSandi, Carmen$$g160090
000213769 773__ $$j26$$k2$$q357-67$$tEur Neuropsychopharmacol
000213769 8564_ $$s1135811$$uhttps://infoscience.epfl.ch/record/213769/files/Cordero_Effects%20of%20partental%20and%20peripubertal%20stress_1.pdf$$yn/a$$zn/a
000213769 909C0 $$0252121$$pLGC$$xU10913
000213769 909C0 $$0252477$$pCIBM$$xU12623
000213769 909CO $$ooai:infoscience.tind.io:213769$$pSB$$pSV$$particle$$qGLOBAL_SET
000213769 917Z8 $$x192880
000213769 917Z8 $$x192880
000213769 917Z8 $$x192880
000213769 917Z8 $$x192880
000213769 917Z8 $$x161735
000213769 917Z8 $$x192880
000213769 917Z8 $$x192880
000213769 937__ $$aEPFL-ARTICLE-213769
000213769 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000213769 980__ $$aARTICLE