000212675 001__ 212675
000212675 005__ 20190416220325.0
000212675 0247_ $$2doi$$a10.1002/anie.201412321
000212675 022__ $$a1433-7851
000212675 02470 $$2ISI$$a000354191600031
000212675 037__ $$aARTICLE
000212675 245__ $$aPlatinum-Catalyzed Domino Reactionwith Benziodoxole Reagents for Accessing Benzene-Alkynylated Indoles
000212675 260__ $$bWiley-Blackwell$$c2015$$aWeinheim
000212675 269__ $$a2015
000212675 300__ $$a5
000212675 336__ $$aJournal Articles
000212675 520__ $$aIndoles are omnipresent in natural products, bioactive molecules, and organic materials. Consequently, their synthesis or functionalization are important fields of research in organic chemistry. Most works focus on installation or modification of the pyrrole ring. To access benzene-ringfunctionalized indoles with an unsubstituted pyrrole ring remains more challenging. Reported herein is a platinumcatalyzed cyclization/alkynylation domino process to selectively obtain C5-or C6-functionalized indoles starting from easily available pyrroles. The work combines, for the first time, a platinum catalyst with ethynylbenziodoxole hypervalent iodine reagents in a domino process for the synthesis of polyfunctionalized arene rings and gives access to important building blocks for the synthesis of bioactive compounds and organic materials.
000212675 6531_ $$aalkynes
000212675 6531_ $$acyclization
000212675 6531_ $$aheterocycles
000212675 6531_ $$ahypervalent compounds
000212675 6531_ $$aplatinum
000212675 700__ $$0246053$$g218174$$aLi, Yifan
000212675 700__ $$aWaser, Jerome$$g181574$$0243584
000212675 773__ $$j54$$tAngewandte Chemie-International Edition$$k18$$q5438-5442
000212675 8564_ $$uhttps://infoscience.epfl.ch/record/212675/files/ACIE2015-5438GreenAccess.pdf$$zn/a$$s4899102$$yn/a
000212675 909C0 $$xU11811$$0252236$$pLCSO
000212675 909CO $$ooai:infoscience.tind.io:212675$$qGLOBAL_SET$$pSB$$particle
000212675 917Z8 $$x181574
000212675 917Z8 $$x181574
000212675 937__ $$aEPFL-ARTICLE-212675
000212675 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000212675 980__ $$aARTICLE