000212521 001__ 212521
000212521 005__ 20181203024021.0
000212521 0247_ $$2doi$$a10.1117/1.Jbo.20.6.066011
000212521 022__ $$a1083-3668
000212521 02470 $$2ISI$$a000358516100030
000212521 037__ $$aARTICLE
000212521 245__ $$aStudy of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy
000212521 269__ $$a2015
000212521 260__ $$bSpie-Soc Photo-Optical Instrumentation Engineers$$c2015$$aBellingham
000212521 300__ $$a5
000212521 336__ $$aJournal Articles
000212521 520__ $$aFluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluorescent. If this bladder washout fluid (BWF) becomes fluorescent, the FC images are frequently degraded. Unfortunately, it is unclear which elements of the diet may contribute to this background fluorescence. We propose to start this exploration with over-the-counter (OTC) vitamin supplements. To this end, we measured excitation-emission matrices of urine samples and the kinetics of modifications of urine fluorescence obtained from nine healthy volunteers before, during, and after intake of a commercially available OTC vitamin supplement. The pharmacokinetics shows that the BWF fluorescence values reach a maximum 8 to 10 h after vitamin intake. They decrease in the half-day that follows and reach values close to baseline similar to 1 day afterward. Based on these results, we conclude that, in order to avoid degradations of fluorescence images, it is likely best that the intake of OTC vitamin supplements be avoided during the week preceding an FC. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
000212521 6531_ $$aphotodetection
000212521 6531_ $$afluorescence spectroscopy
000212521 6531_ $$abackground fluorescence
000212521 6531_ $$aurinary bladder
000212521 700__ $$0246077$$g110512$$uEcole Polytech Fed Lausanne, Swiss Fed Inst Technol, Med Photon Grp, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland$$aZellweger, Matthieu
000212521 700__ $$0245760$$g206959$$uEcole Polytech Fed Lausanne, Swiss Fed Inst Technol, Med Photon Grp, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland$$aMartoccia, Carla
000212521 700__ $$aMengin, Matthieu
000212521 700__ $$aIselin, Christophe
000212521 700__ $$0240886$$g106613$$aVan Den Bergh, Hubert
000212521 700__ $$aWagnieres, Georges$$uEcole Polytech Fed Lausanne, Swiss Fed Inst Technol, Med Photon Grp, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland$$g106697$$0241203
000212521 773__ $$j20$$tJournal Of Biomedical Optics$$k6$$q066011
000212521 909C0 $$0252512$$pGPM
000212521 909C0 $$0252359$$pGR-VDB
000212521 909CO $$pSB$$pSTI$$particle$$ooai:infoscience.tind.io:212521
000212521 917Z8 $$x106697
000212521 937__ $$aEPFL-ARTICLE-212521
000212521 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000212521 980__ $$aARTICLE