Iridium-Stabilized pi-Selenocyclohexadienyls: Synthesis, Molecular Structure, and Cytotoxicity

A series of iridium-stabilized selenocyclohexadienyls of general formula [Cp*Ir((5)-C6H5-nMenSe)][BF4] {Cp* = (5)-C5Me5, n = 0, n = 1, and n = 3} is described, with the selenocyclohexadienyl unit being isolated for the first time by -coordination to a Cp*Ir moiety. The solid-state structure of one of [Cp*Ir((5)-C6H2Me3Se)][BF4] was determined by single-crystal X-ray diffraction analysis. These compounds are obtained in good yields as orange-red microcrystalline solids by halogen displacement from the related -bonded arene-chlorinated starting materials using Na2Se as the selenium source. Furthermore, these new compounds display relevant cytotoxic properties towards human ovarian cancer cells.


Published in:
Synlett, 26, 11, 1563-1566
Year:
2015
Publisher:
Stuttgart, Georg Thieme Verlag Kg
ISSN:
0936-5214
Keywords:
Laboratories:




 Record created 2015-09-28, last modified 2018-03-17


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