Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromanes and Phthalides

The demand for efficient chiral cyclopentadienyl ligands (Cp-x) has increased significantly in recent years, partly because Cp*Rh(III) species have been developed as powerful catalysts for directed C-H functionalization reactions. However, a lack of suitable Cp-x ligands has hampered the development of the corresponding enantioselective processes. We report expansions of the libraries of two generations of Cp-x ligands and their corresponding rhodium(I) complexes. The potential of the rhodium complexes as catalysts was evaluated in enantioselective C-H functionalizations involving cyclizations across tethered aldehydes. The mild reaction conditions permit the syntheses of hydroxychromanes and phthalides in good yields and high enantioselectivities.


Published in:
Synlett, 26, 11, 1490-1495
Year:
2015
Publisher:
Stuttgart, Georg Thieme Verlag Kg
ISSN:
0936-5214
Keywords:
Laboratories:




 Record created 2015-09-28, last modified 2018-03-17


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