Loading...
research article
DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization
2015
The flavo-enzyme DprE1 catalyzes a key epimerization step in the decaprenyl-phosphoryl d-arabinose (DPA) pathway, which is essential for mycobacterial cell wall biogenesis and targeted by several new tuberculosis drug candidates. Here, using differential radiolabeling with DPA precursors and high-resolution fluorescence microscopy, we disclose the unexpected extracytoplasmic localization of DprE1 and periplasmic synthesis of DPA. Collectively, this explains the vulnerability of DprE1 and the remarkable potency of the best inhibitors.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000358395300008
Authors
Brecik, Miroslav
•
Centarova, Ivana
•
•
Kolly, Gaelle S.
•
Huszar, Stanislav
•
Bobovska, Adela
•
Kilacskova, Emoeke
•
Mokosova, Veronika
•
Svetlikova, Zuzana
•
Sarkan, Michal
Publication date
2015
Publisher
Published in
Volume
10
Issue
7
Start page
1631
End page
1636
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 28, 2015