Using a transformation based, at least in part, on a non-simple orthogonal matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. The transformation may be combined with methods from forward error correction to lower the required transmission power.