The design, realization, and preliminary test of a portable wireless system for measuring key metabolites (e.g., glucose, lactate, calcium, potassium, etc..) in intensive cure monitoring is presented. The system is composed by a 3D-Printed case, which includes the fluidic system that drives the monitored human fluids on top of the sensing devices. The case fully integrates a hardware platform on PCB that connects the biosensors to the read-out frontend and to a Bluetooth® module for the data transmission to a mobile Android interface for vital signs visualization. Preliminary in-vitro tests on calibration for some key metabolites of interest are presented.