000210975 001__ 210975
000210975 005__ 20190317000243.0
000210975 037__ $$aPOST_TALK
000210975 245__ $$aCharacterization of intracellular metabolic states in the origin of the metabolic reprogramming of cancer cells
000210975 269__ $$a2015
000210975 260__ $$c2015
000210975 336__ $$aPosters
000210975 520__ $$aCancer cells have been observed to undergo a metabolic reprogramming in which glycolytic fluxes are upregulated whereas oxidative phosphorylation is downregulated. This metabolic phenotype is known as the Warburg effect and it is observed even under high oxygen conditions. To study the mechanism behind this metabolic reprogramming: - We build a reduced model (RedHuman) from the GEM Recon 2 that is representative of the central carbon metabolism of mammalian cells; - We combine fluxomics and metabolomics data to simulate a normal mammalian cells metabolic phenotype during exponential growth phase and the metabolic phenotype of a cancer cell; - We then analyze the feasible flux ranges of the two simulated metabolic phenotypes.
000210975 700__ $$0246111$$g183193$$aPinto Vieira, Joana Raquel
000210975 700__ $$0245962$$g215631$$aAtaman, Meriç
000210975 700__ $$aHatzimanikatis, Vassily$$g174688$$0240657
000210975 7112_ $$dJuly 12-16, 2015$$cPuerto Vallarta, Mexico$$aBiochemical and Molecular Engineering XIX
000210975 8564_ $$uhttps://infoscience.epfl.ch/record/210975/files/BMEC_2015_JV.pdf$$zn/a$$s2555252$$yn/a
000210975 909C0 $$xU11422$$0252131$$pLCSB
000210975 909CO $$ooai:infoscience.tind.io:210975$$qGLOBAL_SET$$pSB$$pposter
000210975 917Z8 $$x183193
000210975 937__ $$aEPFL-POSTER-210975
000210975 973__ $$aOTHER
000210975 980__ $$aPOSTER