000210947 001__ 210947
000210947 005__ 20190604054659.0
000210947 022__ $$a0958-1669
000210947 02470 $$2ISI$$a000367116700019
000210947 0247_ $$2doi$$a10.1016/j.copbio.2015.08.019
000210947 037__ $$aARTICLE
000210947 245__ $$aRites of passage: requirements and standards for building kinetic models of metabolic phenotypes
000210947 269__ $$a2015
000210947 260__ $$bElsevier$$c2015
000210947 336__ $$aJournal Articles
000210947 520__ $$aThe overarching ambition of kinetic metabolic modeling is to capture the dynamic behavior of metabolism to such an extent that systems and synthetic biology strategies can reliably be tested in silico. The lack of kinetic data hampers the development of kinetic models, and most of the current models use ad hoc reduced stoichiometry or oversimplified kinetic rate expressions, which may limit their predictive strength. There is a need to introduce the community-level standards that will organize and accelerate the future developments in this area. We introduce here a set of requirements that will ensure the model quality, we examine the current kinetic models with respect to these requirements, and we propose a general workflow for constructing models that satisfy these requirements.
000210947 6531_ $$akinetic models
000210947 6531_ $$ametabolic engineering
000210947 6531_ $$asynthetic biology
000210947 6531_ $$asystems biology
000210947 700__ $$0240448$$g133818$$aMiskovic, Ljubisa
000210947 700__ $$0248124$$g240700$$aTokic, Milenko
000210947 700__ $$g241502$$0247694$$aFengos, Georgios
000210947 700__ $$0240657$$g174688$$aHatzimanikatis, Vassily
000210947 773__ $$j36$$tCurrent Opinion in Biotechnology$$q146-153
000210947 8564_ $$uhttps://infoscience.epfl.ch/record/210947/files/1-s2.0-S0958166915001184-main.pdf$$zn/a$$s738846$$yn/a
000210947 909C0 $$xU11422$$0252131$$pLCSB
000210947 909CO $$ooai:infoscience.tind.io:210947$$qGLOBAL_SET$$pSB$$particle
000210947 917Z8 $$x133818
000210947 917Z8 $$x148230
000210947 937__ $$aEPFL-ARTICLE-210947
000210947 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000210947 980__ $$aARTICLE