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000210758 005__ 20190317000238.0
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000210758 02470 $$2PMID$$a26283353
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000210758 0247_ $$2doi$$a10.1073/pnas.1504242112
000210758 037__ $$aARTICLE
000210758 245__ $$aBrain system for mental orientation in space, time, and person
000210758 269__ $$a2015
000210758 260__ $$aWashington$$bNatl Acad Sciences$$c2015
000210758 300__ $$a6
000210758 336__ $$aJournal Articles
000210758 520__ $$aOrientation is a fundamental mental function that processes the relations between the behaving self to space (places), time (events), and person (people). Behavioral and neuroimaging studies have hinted at interrelations between processing of these three domains. To unravel the neurocognitive basis of orientation, we used high-resolution 7T functional MRI as 16 subjects compared their subjective distance to different places, events, or people. Analysis at the individual-subject level revealed cortical activation related to orientation in space, time, and person in a precisely localized set of structures in the precuneus, inferior parietal, and medial frontal cortex. Comparison of orientation domains revealed a consistent order of cortical activity inside the precuneus and inferior parietal lobes, with space orientation activating posterior regions, followed anteriorly by person and then time. Core regions at the precuneus and inferior parietal lobe were activated for multiple orientation domains, suggesting also common processing for orientation across domains. The medial prefrontal cortex showed a posterior activation for time and anterior for person. Finally, the default-mode network, identified in a separate resting-state scan, was active for all orientation domains and overlapped mostly with person-orientation regions. These findings suggest that mental orientation in space, time, and person is managed by a specific brain system with a highly ordered internal organization, closely related to the default-mode network.
000210758 6531_ $$aCIBM-AIT
000210758 700__ $$aPeer, Michael
000210758 700__ $$0245162$$aSalomon, Roy$$g209116
000210758 700__ $$aGoldberg, Ilan
000210758 700__ $$0240593$$aBlanke, Olaf$$g165806
000210758 700__ $$aArzy, Shahar
000210758 773__ $$j112$$k35$$q11072-11077$$tProceedings of the National Academy of Sciences of the United States of America
000210758 8564_ $$s1079078$$uhttps://infoscience.epfl.ch/record/210758/files/PNAS-2015-Peer-1504242112.pdf$$yPublisher's version$$zPublisher's version
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000210758 909C0 $$0252477$$pCIBM$$xU12623
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000210758 937__ $$aEPFL-ARTICLE-210758
000210758 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
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