Genetic targeting of chemical indicators in vivo

Fluorescent protein reporters have become the mainstay for tracing cellular circuitry in vivo but are limited in their versatility. Here we generated Cre-dependent reporter mice expressing the Snap-tag to target synthetic indicators to cells. Snap-tag labeling worked efficiently and selectively in vivo, allowing for both the manipulation of behavior and monitoring of cellular fluorescence from the same reporter.


Published in:
Nature Methods, 12, 2, 137-139
Year:
2015
Publisher:
London, Nature Publishing Group
ISSN:
1548-7091
Laboratories:




 Record created 2015-05-29, last modified 2018-03-17


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