000208590 001__ 208590
000208590 005__ 20180913063132.0
000208590 0247_ $$2doi$$a10.1088/1741-2560/12/1/016016
000208590 022__ $$a1741-2560
000208590 02470 $$2ISI$$a000348762500018
000208590 037__ $$aARTICLE
000208590 245__ $$aA three-dimensional self-opening intraneural peripheral interface (SELINE)
000208590 260__ $$aBristol$$bIop Publishing Ltd$$c2015
000208590 269__ $$a2015
000208590 300__ $$a13
000208590 336__ $$aJournal Articles
000208590 520__ $$aObjective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that provides an anchorage system to the nerve and confers stability after implant. This geometry has been achieved by means of the plastic deformation of polyimide. Mechanical and electrochemical characterizations have been performed to prove the integrity of the electrode with very good results. Functionality of SELINEs for fascicular stimulation has been tested during in vivo acute experiments in the rat. Chronic implants were made to test the biocompatibility of the device. Main results. Results showed that SELINEs significantly improve mechanical anchorage to the nerve. Stimulation stability is considerably enhanced compared to common planar transversal electrodes and stimulation selectivity is increased for some motor fascicles. Chronic experimental results showed that SELINEs neither produce changes in the fascicular organization of sciatic nerves nor signs of nerve degeneration. Significance. The presented three-dimensional electrode provides an effective anchorage system to the nervous tissue that can improve the stability of the implant for acute and chronic studies.
000208590 6531_ $$aneural interfaces
000208590 6531_ $$aself opening electrodes
000208590 6531_ $$aperipheral nervous system
000208590 6531_ $$apolyimide
000208590 6531_ $$athin film electrode
000208590 6531_ $$aSELINE
000208590 700__ $$aCutrone, A.$$uScuola Super Sant Anna, Biorobot Inst, I-56025 Pontedera, PI, Italy
000208590 700__ $$aDel Valle, J.$$uUniv Autonoma Barcelona, Inst Neurosci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
000208590 700__ $$aSantos, D.$$uUniv Autonoma Barcelona, Inst Neurosci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
000208590 700__ $$aBadia, J.$$uUniv Autonoma Barcelona, Inst Neurosci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
000208590 700__ $$aFilippeschi, C.$$uIst Italiano Tecnol, Ctr MicroBioRobot SSSA, I-56025 Pontedera, PI, Italy
000208590 700__ $$0246201$$aMicera, S.$$g218366$$uScuola Super Sant Anna, Biorobot Inst, I-56025 Pontedera, PI, Italy
000208590 700__ $$aNavarro, X.$$uUniv Autonoma Barcelona, Inst Neurosci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
000208590 700__ $$aBossi, S.$$uScuola Super Sant Anna, Biorobot Inst, I-56025 Pontedera, PI, Italy
000208590 773__ $$j12$$k1$$tJournal Of Neural Engineering
000208590 909C0 $$0252419$$pTNE$$xU12522
000208590 909CO $$ooai:infoscience.tind.io:208590$$pSTI$$particle
000208590 917Z8 $$x218366
000208590 937__ $$aEPFL-ARTICLE-208590
000208590 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000208590 980__ $$aARTICLE