One-Pot, Three-Component Arylalkynyl Sulfone Synthesis

A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO.SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.


Published in:
Organic Letters, 17, 3, 736-739
Year:
2015
ISSN:
1523-7060
Laboratories:




 Record created 2015-05-29, last modified 2018-12-03

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