000208416 001__ 208416
000208416 005__ 20180913063128.0
000208416 0247_ $$2doi$$a10.1039/c4bm00264d
000208416 022__ $$a2047-4830
000208416 02470 $$2ISI$$a000348202600006
000208416 037__ $$aARTICLE
000208416 245__ $$aSignificance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona
000208416 260__ $$aCambridge$$bRoyal Soc Chemistry$$c2015
000208416 269__ $$a2015
000208416 300__ $$a14
000208416 336__ $$aJournal Articles
000208416 520__ $$aAs nanoparticles (NPs) are increasingly used in many applications their safety and efficient applications in nanomedicine have become concerns. Protein coronas on nanomaterials' surfaces can influence how the cell "recognizes" nanoparticles, as well as the in vitro and in vivo NPs' behaviors. The SuperParamagnetic Iron Oxide Nanoparticle (SPION) is one of the most prominent agents because of its superparamagnetic properties, which is useful for separation applications. To mimic surface properties of different types of NPs, a core-shell SPION library was prepared by coating with different surfaces: polyvinyl alcohol polymer (PVA) (positive, neutral and negative), SiO2 (positive and negative), titanium dioxide and metal gold. The SPIONs with different surfaces were incubated at a fixed serum : nanoparticle surface ratio, magnetically trapped and washed. The tightly bound proteins were quantified and identified. The surface charge has a great impact on protein adsorption, especially on PVA and silica where proteins preferred binding to the neutral and positively charged surfaces. The importance of surface material on protein adsorption was also revealed by preferential binding on TiO2 and gold coated SPION, even negatively charged. There is no correlation between the protein net charge and the nanoparticle surface charge on protein binding, nor direct correlation between the serum proteins' concentration and the proteins detected in the coronas.
000208416 700__ $$0242589$$aSakulkhu, Usawadee$$g187358$$uEcole Polytech Fed Lausanne, Lab Powder Technol, Lausanne, Switzerland
000208416 700__ $$aMahmoudi, Morteza$$uUniv Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran
000208416 700__ $$aMaurizi, Lionel$$uEcole Polytech Fed Lausanne, Lab Powder Technol, Lausanne, Switzerland
000208416 700__ $$aCoullerez, Geraldine$$uEcole Polytech Fed Lausanne, Lab Powder Technol, Lausanne, Switzerland
000208416 700__ $$0240861$$aHofmann-Amtenbrink, Margarethe$$g113472$$uMat Search Consulting Hofmann, CH-1009 Pully, Switzerland
000208416 700__ $$aVries, Marcel$$uUniv Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
000208416 700__ $$aMotazacker, Mahdi
000208416 700__ $$aRezaee, Farhad$$uUniv Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
000208416 700__ $$0240408$$aHofmann, Heinrich$$g105410$$uEcole Polytech Fed Lausanne, Lab Powder Technol, Lausanne, Switzerland
000208416 773__ $$j3$$k2$$q265-278$$tBiomaterials Science
000208416 909C0 $$0252068$$pLTP$$xU10340
000208416 909CO $$ooai:infoscience.tind.io:208416$$pSTI$$particle
000208416 917Z8 $$x105410
000208416 937__ $$aEPFL-ARTICLE-208416
000208416 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000208416 980__ $$aARTICLE