000208264 001__ 208264
000208264 005__ 20181203023855.0
000208264 022__ $$a0955-0674
000208264 02470 $$2ISI$$a000352226700006
000208264 0247_ $$2doi$$a10.1016/j.ceb.2014.10.007
000208264 037__ $$aARTICLE
000208264 245__ $$aMolecular basis for the regulation of the nuclear receptor LRH-1
000208264 269__ $$a2015
000208264 260__ $$aLondon$$bCurrent Biology Ltd$$c2015
000208264 300__ $$a9
000208264 336__ $$aJournal Articles
000208264 520__ $$aLiver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies suggest that specific phospholipids act as endogenous LRH-1 ligands. Although binding of ligands may enhance its transcriptional activation, posttranslational modifications (PTMs) and binding of coregulators and other NRs have emerged as mechanisms to fine-tune the selective regulation of LRH-1 target genes. In this review article, we will discuss how LRH-1 is regulated by PTMs and binding of ligands and coregulators, and explain some metabolic consequences with a special focus on liver physiology.
000208264 700__ $$aStein, Sokrates
000208264 700__ $$0240041$$aSchoonjans, Kristina$$g183105
000208264 773__ $$j33$$q26-34$$tCurrent Opinion In Cell Biology
000208264 909C0 $$0252495$$pUPSCHOONJANS$$xU12735
000208264 909CO $$ooai:infoscience.tind.io:208264$$pSV$$particle
000208264 917Z8 $$x183105
000208264 937__ $$aEPFL-ARTICLE-208264
000208264 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000208264 980__ $$aARTICLE