Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes

Following the identification of [Ru(eta(6)-p-cymene)Cl-2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of structurally related compounds were designed. In the new derivatives, the p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric bulk or aquation kinetics. The new compounds were evaluated in both in vitro (cytotoxicity and migration assays) and in vivo (chicken chorioallantoic membrane) models and were found to exhibit potent antivascular effects.


Published in:
Journal Of Medicinal Chemistry, 58, 8, 3356-3365
Year:
2015
Publisher:
Washington, Amer Chemical Soc
ISSN:
0022-2623
Laboratories:




 Record created 2015-05-29, last modified 2018-03-17


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